Structure of PDB 5czx Chain A

Receptor sequence
>5czxA (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
CPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRL
FNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQ
GCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLS
AILRTSLRFRLDAHGQAMVFPYHVIGSVVMLEIDNRLCLQNDHCFPDAQS
AADYLGALSAVERLDFPYPLRDVRGEP
3D structure
PDB5czx Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A K1395 D1398 R1400 D1402 D1413 D1416 K9 D12 R14 D16 D27 D30
BS02 CA A L1436 N1439 R1441 D1443 D1454 L50 N53 R55 D57 D68
BS03 CA A H1478 D1481 R1483 D1485 D1496 D1499 H92 D95 R97 D99 D110 D113
Gene Ontology
Molecular Function
GO:0038023 signaling receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5czx, PDBe:5czx, PDBj:5czx
PDBsum5czx
PubMed27157619
UniProtQ9UM47|NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (Gene Name=NOTCH3)

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