Structure of PDB 5cy9 Chain A

Receptor sequence
>5cy9A (length=131) Species: 9606 (Homo sapiens) [Search protein sequence]
HLVPRGSNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQP
VDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNC
YIYNKPGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB5cy9 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E0A A F83 V87 L92 N140 I146 M149 F47 V51 L56 N104 I110 M113 MOAD: Kd=0.218uM
PDBbind-CN: -logKd/Ki=6.66,Kd=0.218uM
BindingDB: Kd=218nM,IC50=730nM
External links
PDB RCSB:5cy9, PDBe:5cy9, PDBj:5cy9
PDBsum5cy9
PubMed26731490
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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