Structure of PDB 5cxv Chain A

Receptor sequence
>5cxvA (length=444) Species: 9606,10665 [Search protein sequence]
KGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLAC
ADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASQASVMNLLLI
SFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVG
ERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRN
IFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGR
NTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINM
VFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITT
FRTGTWDAYFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCV
PETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDK
3D structure
PDB5cxv Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1010 D1019
Catalytic site (residue number reindexed from 1) E209 D218
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N60 R137 S356 V358 E360 A363 N41 R118 S361 V363 E365 A368
BS02 0HK A D105 Y106 S109 W157 T189 T192 A193 A196 W378 Y381 N382 Y404 C407 D86 Y87 S90 W138 T170 T173 A174 A177 W383 Y386 N387 Y409 C412
BS03 Y01 A F50 K57 Y62 C69 W150 F31 K38 Y43 C50 W131
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016907 G protein-coupled acetylcholine receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0040012 regulation of locomotion
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
GO:0046541 saliva secretion
GO:0050890 cognition
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cxv, PDBe:5cxv, PDBj:5cxv
PDBsum5cxv
PubMed26958838
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P11229|ACM1_HUMAN Muscarinic acetylcholine receptor M1 (Gene Name=CHRM1)

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