Structure of PDB 5cxi Chain A

Receptor sequence
>5cxiA (length=180) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
QRERRKRILDATMAIASKGGYEAVQMRAVADRADVAVGTLYRYFPSKVHL
LVSALGREFSRIDAKTDRSAAGATPFQRLNFMVGKLNRAMQRNPLLTEAM
TRAYVFADASAASEVDQVEKLIDSMFARAMANGEPTEDQYHIARVISDVW
LSNLLAWLTRRASATDVSKRLDLAVRLLIG
3D structure
PDB5cxi The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5TW A L68 E71 F72 A103 M104 L110 Y118 S161 W164 L55 E58 F59 A89 M90 L96 Y104 S147 W150 MOAD: Kd=280nM
PDBbind-CN: -logKd/Ki=6.55,Kd=280nM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5cxi, PDBe:5cxi, PDBj:5cxi
PDBsum5cxi
PubMed26858250
UniProtP96856|KSTR_MYCTU HTH-type transcriptional repressor KstR (Gene Name=kstR)

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