Structure of PDB 5cw8 Chain A

Receptor sequence
>5cw8A (length=176) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
EAQRERRKRILDATMAIASKGGYEAVQMRAVADRADVAVGTLYRYFPSKV
HLLVSALGREFSRIDAAGATPFQRLNFMVGKLNRAMQRNPLLTEAMTRAY
VFADASAASEVDQVEKLIDSMFARAMANGEPTEDQYHIARVISDVWLSNL
LAWLTRRASATDVSKRLDLAVRLLIG
3D structure
PDB5cw8 The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
ChainA
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 55X A E71 F72 N107 Y118 S161 W164 L168 E60 F61 N89 Y100 S143 W146 L150 PDBbind-CN: -logKd/Ki=7.22,Kd=60nM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5cw8, PDBe:5cw8, PDBj:5cw8
PDBsum5cw8
PubMed26858250
UniProtP96856|KSTR_MYCTU HTH-type transcriptional repressor KstR (Gene Name=kstR)

[Back to BioLiP]