Structure of PDB 5cvf Chain A

Receptor sequence
>5cvfA (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSE
VFEAINITNNEKVVVKILKPVAKIKREIKILENLRGGPNIITLADIVKDP
VSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH
RDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV
DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL
YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL
LRYDHQSRLTAREAMEHPYFYTVVK
3D structure
PDB5cvf Specific inhibition of CK2 alpha from an anchor outside the active site.
ChainA
Resolution1.63 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 K158 N161 D175 P184 S194
Catalytic site (residue number reindexed from 1) D152 K154 N157 D171 P180 S190
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 54Z A L124 L128 Y136 P159 V162 I164 M225 L120 L124 Y132 P155 V158 I160 M221
BS02 ATP A G48 S51 V53 V66 K68 V116 M163 I174 D175 G46 S49 V51 V64 K66 V112 M159 I170 D171
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5cvf, PDBe:5cvf, PDBj:5cvf
PDBsum5cvf
PubMed28451126
UniProtP68400|CSK21_HUMAN Casein kinase II subunit alpha (Gene Name=CSNK2A1)

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