Structure of PDB 5cvd Chain A

Receptor sequence
>5cvdA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
GLVPRGSHMTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDI
NSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDI
TEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLT
DQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRR
IICSAGLSLLAEERQENLPDEIYHVYSFALR
3D structure
PDB5cvd Molecular basis for histone N-terminal methylation by NRMT1
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.244: protein N-terminal methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W20 L31 Y34 W136 D180 D212 E213 I214 Y215 W28 L39 Y42 W144 D188 D220 E221 I222 Y223
BS02 SAH A W20 G69 G71 R74 I75 D91 I92 T93 F96 G118 L119 W136 V137 H140 W28 G77 G79 R82 I83 D99 I100 T101 F104 G126 L127 W144 V145 H148
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0071885 N-terminal protein N-methyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006480 N-terminal protein amino acid methylation
GO:0007051 spindle organization
GO:0007059 chromosome segregation
GO:0018012 N-terminal peptidyl-alanine trimethylation
GO:0018013 N-terminal peptidyl-glycine methylation
GO:0018016 N-terminal peptidyl-proline dimethylation
GO:0032259 methylation
GO:0035572 N-terminal peptidyl-serine dimethylation
GO:0035573 N-terminal peptidyl-serine trimethylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cvd, PDBe:5cvd, PDBj:5cvd
PDBsum5cvd
PubMed26543159
UniProtQ9BV86|NTM1A_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Gene Name=NTMT1)

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