Structure of PDB 5cuu Chain A

Receptor sequence
>5cuuA (length=378) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
NSYIGTGLDTSLENVKPLPEACKRNVTEFDLVAYGKDEFTLSMEKRVMAR
MFSAFDVTQLGYLEERKIEHMCKYLGRVMNEDDVKQMKSEINAIDGHITF
EKFWAWWCSHPEVPAKKDFFSMVSVDFAVPYHQQQLLTRETGELYTPSYR
VLYYFRDMETGKELQVSPWHDIPLYVRDLVRTKPASLPMNRYNFICEIPK
WTRAKFEIATGEPFNPIKQDIKNGVPRFYKHGDMMWNYGALPQTWESTDV
VFEGGYVGDNDPIDAIEIGMTQFKVGQVGAVKVLGILGMIDDGQMDWKVI
CISHNDPICRFLKDIHDVPKFLPGCLDAIHEWFRVYKICQGGVENKFVFN
GEFKDKSFAMKVIDESHYMWGNLRKINK
3D structure
PDB5cuu Crystal structure of Trypanosoma cruzi protein in complex with ligand
ChainA
Resolution2.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4GA A K237 D323 K369 K205 D291 K337 PDBbind-CN: -logKd/Ki=4.37,IC50=42.3uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006796 phosphate-containing compound metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cuu, PDBe:5cuu, PDBj:5cuu
PDBsum5cuu
PubMed
UniProtQ4JH30

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