Structure of PDB 5cuq Chain A

Receptor sequence
>5cuqA (length=257) Species: 11069 (dengue virus type 3) [Search protein sequence]
GETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAV
SRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTK
GGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPT
VEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLV
RNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDV
DLGAGTR
3D structure
PDB5cuq Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase.
ChainA
Resolution1.696 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NSC A G81 G109 H110 D131 V132 F133 G76 G104 H105 D126 V127 F128 MOAD: ic50=7.7uM
PDBbind-CN: -logKd/Ki=5.92,IC50=1.2uM
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5cuq, PDBe:5cuq, PDBj:5cuq
PDBsum5cuq
PubMed26726314
UniProtC0LMU0

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