Structure of PDB 5ctv Chain A

Receptor sequence
>5ctvA (length=176) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
ASMEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWRKDPE
LGFFSHIVGNGAIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEF
MTDYRLYIELLRNLADEAGLPKTLDTGSLAGIKTAEYATNNQPNNHSDHV
DPYPYLAKWGISREQFKHDIENGLTI
3D structure
PDB5ctv The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.
ChainA
Resolution1.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.28: N-acetylmuramoyl-L-alanine amidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E48 W72 D73 G75 N79 H144 S145 H147 E50 W74 D75 G77 N81 H146 S147 H149
BS02 AMV A Y41 R44 Y43 R46
BS03 AMV A H26 S27 T28 E87 H147 D149 H28 S29 T30 E89 H149 D151
Gene Ontology
Molecular Function
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
Biological Process
GO:0009253 peptidoglycan catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5ctv, PDBe:5ctv, PDBj:5ctv
PDBsum5ctv
PubMed27273793
UniProtP06653|ALYS_STRPN Autolysin (Gene Name=lytA)

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