Structure of PDB 5csh Chain A

Receptor sequence
>5cshA (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEV
FEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKD
PVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIM
HRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL
VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTED
LYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDK
LLRYDHQSRLTAREAMEHPYFYTV
3D structure
PDB5csh Specific inhibition of CK2 alpha from an anchor outside the active site.
ChainA
Resolution1.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 K158 N161 D175 P184 S194
Catalytic site (residue number reindexed from 1) D153 K155 N158 D172 P181 S191
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 54E A F121 P159 V162 I164 M225 F118 P156 V159 I161 M222 MOAD: Kd=270uM
PDBbind-CN: -logKd/Ki=3.57,Kd=270uM
BindingDB: IC50=500000nM
BS02 54E A Y39 I69 D103 T108 A110 Y36 I66 D100 T105 A107 MOAD: Kd=270uM
PDBbind-CN: -logKd/Ki=3.57,Kd=270uM
BindingDB: IC50=500000nM
BS03 ATP A V66 V116 M163 V63 V113 M160
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5csh, PDBe:5csh, PDBj:5csh
PDBsum5csh
PubMed28451126
UniProtP68400|CSK21_HUMAN Casein kinase II subunit alpha (Gene Name=CSNK2A1)

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