Structure of PDB 5cs8 Chain A

Receptor sequence
>5cs8A (length=133) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHHLVPRGSNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWP
FQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTM
FTNCYIYNKPGDDIVLMAEALEKLFLQKINELP
3D structure
PDB5cs8 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EB8 A W81 F83 L94 N140 I146 M149 W49 F51 L62 N108 I114 M117 MOAD: ic50=2.29uM
BindingDB: IC50=2290nM
External links
PDB RCSB:5cs8, PDBe:5cs8, PDBj:5cs8
PDBsum5cs8
PubMed26731490
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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