Structure of PDB 5cr0 Chain A

Receptor sequence
>5cr0A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKH
YSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVD
VAITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRL
PGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSE
HALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
3D structure
PDB5cr0 Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D98 D100 D161
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W342 G343 G345 K347 T348 D427 D429 R488 D490 Y505 F506 T507 A510 N513 W13 G14 G16 K18 T19 D98 D100 R159 D161 Y176 F177 T178 A181 N184
BS02 dna A Q372 S463 Q464 R514 R517 A518 K521 E529 Q43 S134 Q135 R185 R188 A189 K192 E200
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5cr0, PDBe:5cr0, PDBj:5cr0
PDBsum5cr0
PubMed26836966
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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