Structure of PDB 5cpm Chain A

Receptor sequence
>5cpmA (length=359) Species: 303 (Pseudomonas putida) [Search protein sequence]
SALFEPYTLKDVTLRNRIAIPPMCQYMAEDGLINDWHQVHYASMARGGAG
LLVVEATAVAPEGRITPGCAGIWSDAHAQAFVPVVQAIKAAGSVPGIQIA
HAGRKASANRPWEGDDHIGADDARGWETIAPSAIAFGAHLPNVPRAMTLD
DIARVKQDFVDAARRARDAGFEWIELHFAHGYLGQSFFSEHSNKRTDAYG
GSFDNRSRFLLETLAAVREVWPENLPLTARFGVLEYDGRDEQTLEESIEL
ARRFKAGGLDLLSVSVGFTIPETNIPWGPAFMGPIAERVRREAKLPVTSA
WGFGTPQLAEAALQANQLDLVSVGRAHLADPHWAYFAAKELGVEKASWTL
PAPYAHWLE
3D structure
PDB5cpm Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes.
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C25 H178 H181 Y183 R231 R240
Catalytic site (residue number reindexed from 1) C24 H177 H180 Y182 R230 R239
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A Y27 H178 H181 Y183 F269 W278 Y26 H177 H180 Y182 F268 W277 MOAD: Kd=27uM
BS02 FNR A P22 P23 M24 C25 A57 Q99 H178 H181 R231 A301 W302 G325 R326 P21 P22 M23 C24 A56 Q98 H177 H180 R230 A300 W301 G324 R325
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003959 NADPH dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050661 NADP binding

View graph for
Molecular Function
External links
PDB RCSB:5cpm, PDBe:5cpm, PDBj:5cpm
PDBsum5cpm
PubMed26727612
UniProtQ9R9V9

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