Structure of PDB 5cp5 Chain A

Receptor sequence
>5cp5A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
PRGSNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDA
VKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIY
NKPGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB5cp5 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EB0 A W81 P82 F83 L92 L94 N140 D145 I146 M149 W42 P43 F44 L53 L55 N101 D106 I107 M110 MOAD: Kd=1.234uM
PDBbind-CN: -logKd/Ki=5.91,Kd=1.234uM
BindingDB: IC50=1530nM,Kd=1234nM
External links
PDB RCSB:5cp5, PDBe:5cp5, PDBj:5cp5
PDBsum5cp5
PubMed26731490
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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