Structure of PDB 5coi Chain A

Receptor sequence
>5coiA (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
HHLVPRGSNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQ
PVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTN
CYIYNKPGDDIVLMAEALEKLFLQKINELPTE
3D structure
PDB5coi Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 55K A W81 P82 F83 L92 L94 N140 M149 W46 P47 F48 L57 L59 N105 M114 MOAD: ic50=2.58uM
BindingDB: IC50=2580nM
External links
PDB RCSB:5coi, PDBe:5coi, PDBj:5coi
PDBsum5coi
PubMed26731490
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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