Structure of PDB 5clp Chain A

Receptor sequence
>5clpA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
GPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSE
VFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK
DPVSRTPALVFEHVNNTDQTLTDYDIRFYMYEILKALDYCHSMGIMHRDV
KPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQ
MYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDY
IDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRY
DHQSRLTAREAMEHPYFYTVVK
3D structure
PDB5clp Specific inhibition of CK2 alpha from an anchor outside the active site.
ChainA
Resolution1.684 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 K158 N161 D175 P184 S194
Catalytic site (residue number reindexed from 1) D149 K151 N154 D168 P177 S187
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 42J A V66 K68 F113 M163 I174 D175 V64 K66 F111 M156 I167 D168 BindingDB: IC50=700000nM
BS02 42J A L45 G46 V53 H160 N161 D175 L43 G44 V51 H153 N154 D168 BindingDB: IC50=700000nM
BS03 42J A Q36 Y39 L41 I69 D103 Q34 Y37 L39 I67 D101 BindingDB: IC50=700000nM
BS04 42J A L128 P159 V162 I164 M221 M225 L121 P152 V155 I157 M214 M218 BindingDB: IC50=700000nM
BS05 42J A E282 V285 Q290 V293 E275 V278 Q283 V286 BindingDB: IC50=700000nM
BS06 42J A E282 R283 V285 H286 E275 R276 V278 H279 BindingDB: IC50=700000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5clp, PDBe:5clp, PDBj:5clp
PDBsum5clp
PubMed28451126
UniProtP68400|CSK21_HUMAN Casein kinase II subunit alpha (Gene Name=CSNK2A1)

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