Structure of PDB 5ckx Chain A

Receptor sequence
>5ckxA (length=448) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
WTVDIPIDPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVPP
VTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRALL
QMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFAP
DAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVRT
SPAGARYEALATEIDRGLRFMSACGVAEIYASHEALVLDYERAMLRLSDG
DDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVKLGPNMTPE
LAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQATGHQVIWQ
CDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPGGIHVEITG
ENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLVAEMLRD
3D structure
PDB5ckx Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A C87 H369 E411 D441 C80 H355 E397 D427
BS02 PHE A F91 R171 N175 F84 R164 N168
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ckx, PDBe:5ckx, PDBj:5ckx
PDBsum5ckx
PubMed26776476
UniProtO53512|AROG_MYCTU Phospho-2-dehydro-3-deoxyheptonate aldolase AroG (Gene Name=aroG)

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