Structure of PDB 5cjf Chain A

Receptor sequence
>5cjfA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
HWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYD
QPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG
SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETK
NIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPP
CYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLN
QRMVFASFIQAGSSYTT
3D structure
PDB5cjf Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.
ChainA
Resolution1.83 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H64 H94 H96 E106 H119 T199
Catalytic site (residue number reindexed from 1) H64 H89 H91 E102 H115 T197
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H94 H96 H119 H89 H91 H115
BS02 520 A H94 H119 S132 L198 T199 T200 H89 H115 S128 L196 T197 T198 MOAD: Ki=0.26nM
PDBbind-CN: -logKd/Ki=9.59,Ki=0.26nM
BindingDB: Ki=0.260000nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5cjf, PDBe:5cjf, PDBj:5cjf
PDBsum5cjf
PubMed26497049
UniProtQ9ULX7|CAH14_HUMAN Carbonic anhydrase 14 (Gene Name=CA14)

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