Structure of PDB 5cj6 Chain A

Receptor sequence
>5cj6A (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACPTSCSRRFYQLTKLLDSVQPIARELH
QFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB5cj6 2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V716 K720 Q733 M734 Q738 M894 E897 V46 K50 Q63 M64 Q68 M220 E223
BS02 51Y A L704 N705 L707 Q711 M745 M749 F764 T877 M895 L34 N35 L37 Q41 M75 M79 F94 T203 M221 MOAD: Ki=2.03nM
PDBbind-CN: -logKd/Ki=8.69,Ki=2.03nM
BindingDB: Ki=2.0nM,EC50=0.499000nM
External links
PDB RCSB:5cj6, PDBe:5cj6, PDBj:5cj6
PDBsum5cj6
PubMed26683992
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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