Structure of PDB 5ciu Chain A

Receptor sequence
>5ciuA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
EYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFG
DGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGK
TFDQLKPMLEWAHGGFKPTGIEGLKPN
3D structure
PDB5ciu Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W246 Q253 W31 Q38
BS02 peptide A K234 F236 W239 K251 W263 D266 K268 F269 K19 F21 W24 K36 W48 D51 K53 F54
External links
PDB RCSB:5ciu, PDBe:5ciu, PDBj:5ciu
PDBsum5ciu
PubMed26993463
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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