Structure of PDB 5cgp Chain A

Receptor sequence
>5cgpA (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNP
MDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLA
EVFEQEIDPVMQSLG
3D structure
PDB5cgp Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.
ChainA
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 53W A P1110 Q1113 V1115 L1120 N1168 R1173 V1174 F1177 P28 Q31 V33 L38 N86 R91 V92 F95 MOAD: Kd=0.12uM
BindingDB: IC50=1.2e+2nM,Kd=1.2e+2nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5cgp, PDBe:5cgp, PDBj:5cgp
PDBsum5cgp
PubMed26670081
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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