Structure of PDB 5cgj Chain A

Receptor sequence
>5cgjA (length=290) Species: 10090 (Mus musculus) [Search protein sequence]
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGL
LYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDG
HIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY
AVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAG
GYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYD
GHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
3D structure
PDB5cgj Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling.
ChainA
Resolution3.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 51M A Y334 S363 G364 R415 R483 Y525 A556 S602 G603 Y11 S40 G41 R92 R160 Y202 A233 S279 G280 PDBbind-CN: -logKd/Ki=5.22,Kd=6uM
BindingDB: Kd=6000nM
External links
PDB RCSB:5cgj, PDBe:5cgj, PDBj:5cgj
PDBsum5cgj
PubMed26459563
UniProtQ9Z2X8|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)

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