Structure of PDB 5cge Chain A

Receptor sequence
>5cgeA (length=255) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]
MNYLNNIRIENPLTICYTNDVVKNFTANGLLSIGASPAMSEAPEEAEEFY
KVAQALLINIGTLTAQNEQDIIAIAQTANEAGLPIVFDPVAVGASTYRKQ
FCKLLLKSAKVSVIKGNASEILALIDDTATLDAVTIAKKAYAIYKTAIVI
TGKEDVIVQGDKAIVLANGSPLLARVTGAGCLLGGIIAGFLFRETEPDIE
ALIEAVSVFNIAAEVAAENENCGGPGTFSPLLLDTLYHLNETTYQQRIRI
QEVEE
3D structure
PDB5cge Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.50: hydroxyethylthiazole kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 51F A A38 M39 A38 M39
BS02 51F A V21 T186 V21 T177
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004417 hydroxyethylthiazole kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009228 thiamine biosynthetic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0016310 phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5cge, PDBe:5cge, PDBj:5cge
PDBsum5cge
PubMed26960569
UniProtQ6GEY3|THIM_STAAR Hydroxyethylthiazole kinase (Gene Name=thiM)

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