Structure of PDB 5cg9 Chain A

Receptor sequence
>5cg9A (length=267) Species: 5762 (Naegleria gruberi) [Search protein sequence]
HMINKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHD
GSVELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYV
TADLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALN
NCLYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLE
LTDKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKP
YYEDTQKNSLKIHKETK
3D structure
PDB5cg9 Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.
ChainA
Resolution2.693 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S148 M149 P150 K303 K318 S94 M95 P96 K249 K264
BS02 dna A Y141 N147 Y153 T155 A156 R224 V293 F295 H297 Q310 Y87 N93 Y99 T101 A102 R170 V239 F241 H243 Q256
BS03 AKG A R224 D231 L240 Y242 L253 H279 V281 R289 R170 D177 L186 Y188 L199 H225 V227 R235
BS04 MN A H229 D231 H279 H175 D177 H225
External links
PDB RCSB:5cg9, PDBe:5cg9, PDBj:5cg9
PDBsum5cg9
PubMed26323320
UniProtD2W6T1|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

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