Structure of PDB 5cg8 Chain A

Receptor sequence

>5cg8A (length=266) Species: 5762 (Naegleria gruberi) [Search protein sequence]

MINKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHDG
SVELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYVT
ADLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALNN
CLYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLEL
TDKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKPY
YEDTQKNSLKIHKETK

3D structure

PDB

5cg8 Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.

Chain

Resolution

2.702 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

1.14.11.80: methylcytosine dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S148 M149 P150 K318	S93 M94 P95 K263
BS02	dna	A	Y141 Y153 T155 A156 R224 D234 V293 F295 H297 Q310 K311	Y86 Y98 T100 A101 R169 D179 V238 F240 H242 Q255 K256
BS03	AKG	A	N214 R224 H229 D231 L240 Y242 L253 H279 V281 R289	N159 R169 H174 D176 L185 Y187 L198 H224 V226 R234
BS04	MN	A	H229 D231 H279	H174 D176 H224

External links

PDB	RCSB:5cg8, PDBe:5cg8, PDBj:5cg8
PDBsum	5cg8
PubMed	26323320
UniProt	D2W6T1\|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

[Back to BioLiP]