Structure of PDB 5cfn Chain A

Receptor sequence
>5cfnA (length=181) Species: 45351 (Nematostella vectensis) [Search protein sequence]
SNVADGLAWSYYFGYLKFVLPELEKQIEKTSKFRSKEKFVKKMFILIPSN
CFWDDKIPGSDYDPQNRITFEGNTEPLEKTRGGVFLRHYKHSVYEIKDGE
NEPWFCIMEYATPLLTLYDMSVAQPGELSREERDAQVVVFLRKLQDILEG
DRACQGKYELVTFSPDRDLADVMLRKLKDSE
3D structure
PDB5cfn Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2BA A Y206 Y280 T303 P304 Y15 Y89 T112 P113
BS02 2BA A R278 H279 T303 R87 H88 T112
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:5cfn, PDBe:5cfn, PDBj:5cfn
PDBsum5cfn
PubMed26300263
UniProtA7SLZ2|STING_NEMVE Stimulator of interferon genes protein (Gene Name=v1g246111)

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