Structure of PDB 5cfm Chain A

Receptor sequence
>5cfmA (length=187) Species: 45351 (Nematostella vectensis) [Search protein sequence]
GSNVADGLAWSYYFGYLKFVLPELEKQIEKTSKFRSKEKFVKKMFILIPS
NCFWDDKIPGSDYDPQNRITFEGNTEPLEKTRGGVFLRHYKHSVYEIKDG
ENEPWFCIMEYATPLLTLYDMSVAQPGELSREERDAQVVVFLRKLQDILE
GDRACQGKYELVTFSPDRDLADVMLRKLKDSELEIGG
3D structure
PDB5cfm Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
ChainA
Resolution1.994 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4BW A Y206 F276 R278 Y280 T303 P304 Y16 F86 R88 Y90 T113 P114 MOAD: Kd=50nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:5cfm, PDBe:5cfm, PDBj:5cfm
PDBsum5cfm
PubMed26300263
UniProtA7SLZ2|STING_NEMVE Stimulator of interferon genes protein (Gene Name=v1g246111)

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