Structure of PDB 5ce8 Chain A

Receptor sequence
>5ce8A (length=296) Species: 999630 (Thermoproteus uzoniensis 768-20) [Search protein sequence]
SMKVWLDGRLVDEEEAKVTVLSPSLNYGFGVFEGIRAYWNGENLYVFRLR
DHMERLLRSAKIIGLDVPYTAEELSKAVVETVRANGFKEDLYIRPVAYIS
KPQISLDVRGLQASVAIAAIPFGKYLKVEGVRAAVVSWRRVHTSMMPVMA
KATGIYLNSIMAAVEARARGYDEAIMLNAEGKVVEGSGENIFIVRRGVLM
TPPLEDGILEGITRETVISIAGDLGIPLLEKSITREELYAADEAFFVGTA
AEITPIIEIDGRVLQRGPITQKIAETYRRIVLGKEEKYLPWLTPVY
3D structure
PDB5ce8 First structure of archaeal branched-chain amino acid aminotransferase from Thermoproteus uzoniensis specific for L-amino acids and R-amines.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F31 K150 E184 L208
Catalytic site (residue number reindexed from 1) F32 K151 E185 L209
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A R54 K150 Y155 E184 E188 L208 G210 I211 T212 T248 R55 K151 Y156 E185 E189 L209 G211 I212 T213 T249
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0008483 transaminase activity
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0046394 carboxylic acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5ce8, PDBe:5ce8, PDBj:5ce8
PDBsum5ce8
PubMed26872794
UniProtF2L0W0

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