Structure of PDB 5ce1 Chain A

Receptor sequence
>5ce1A (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
EPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRA
LTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAA
ICQDCGRRKLIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAA
HCFPERNRVLSRWRVFAGAVAQASGLQLGVQAVVYHGGYLPFRPNSENSN
DIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQA
GVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGP
FVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKT
HSEASGMVTQL
3D structure
PDB5ce1 Crystal Structure of Serine protease Hepsin in complex with Inhibitor
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H203 D257 Q350 G351 D352 S353 G354
Catalytic site (residue number reindexed from 1) H151 D201 Q294 G295 D296 S297 G298
Enzyme Commision number 3.4.21.106: hepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 50K A H203 D347 A348 Q350 V375 W377 G380 H151 D291 A292 Q294 V319 W321 G324 BindingDB: Ki=100nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0070008 serine-type exopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:5ce1, PDBe:5ce1, PDBj:5ce1
PDBsum5ce1
PubMed
UniProtP05981|HEPS_HUMAN Serine protease hepsin (Gene Name=HPN)

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