Structure of PDB 5cc0 Chain A

Receptor sequence
>5cc0A (length=73) Species: 32630 (synthetic construct) [Search protein sequence]
QKVCLICGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDK
IRRKNCPACRLRKCLQAGMTLGA
3D structure
PDB5cc0 Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
ChainA
Resolution2.405 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A C431 H432 Y433 K442 K446 C14 H15 Y16 K25 K29 PDBbind-CN: Kd=0.369uM
BS02 dna A G439 S440 F444 R447 R470 K471 R477 G22 S23 F27 R30 R53 K54 R60 PDBbind-CN: Kd=0.369uM
BS03 ZN A C421 C424 C438 C441 C4 C7 C21 C24
BS04 ZN A C457 C463 C473 C476 C40 C46 C56 C59
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5cc0, PDBe:5cc0, PDBj:5cc0
PDBsum5cc0
PubMed26715749
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

[Back to BioLiP]