Structure of PDB 5cbx Chain A

Receptor sequence
>5cbxA (length=72) Species: 32644 (unidentified) [Search protein sequence]
KICLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKI
RRKNCPACRFRKCLQAGMNLEA
3D structure
PDB5cbx Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A C431 H432 Y433 K446 C13 H14 Y15 K28 PDBbind-CN: Kd=0.11uM
BS02 dna A S440 R447 R470 K471 R477 S22 R29 R52 K53 R59 PDBbind-CN: Kd=0.11uM
BS03 ZN A C421 C424 C438 C441 C3 C6 C20 C23
BS04 ZN A C457 C463 C473 C476 C39 C45 C55 C58
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5cbx, PDBe:5cbx, PDBj:5cbx
PDBsum5cbx
PubMed26715749
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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