Structure of PDB 5cbs Chain A

Receptor sequence
>5cbsA (length=260) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK
WWYDKGECGS
3D structure
PDB5cbs Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
ChainA
Resolution1.801 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E42 A Y58 L87 T88 R93 I108 S139 E190 D213 K215 Y58 L87 T88 R93 I108 S139 E190 D213 K215 MOAD: Kd=3.9uM
PDBbind-CN: -logKd/Ki=5.41,Kd=3.90uM
BindingDB: Ki=24000nM,IC50=6300nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5cbs, PDBe:5cbs, PDBj:5cbs
PDBsum5cbs
PubMed26653877
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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