Structure of PDB 5cbr Chain A

Receptor sequence
>5cbrA (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK
WWYDKGEC
3D structure
PDB5cbr Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
ChainA
Resolution1.996 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4ZK A Y58 P86 T88 R93 L135 S139 T140 T171 Y187 L189 E190 M193 Y217 Y58 P86 T88 R93 L135 S139 T140 T171 Y187 L189 E190 M193 Y217 MOAD: Kd=1.8uM
PDBbind-CN: -logKd/Ki=5.74,Kd=1.80uM
BindingDB: Ki=1740nM,IC50=3700nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5cbr, PDBe:5cbr, PDBj:5cbr
PDBsum5cbr
PubMed26653877
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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