Structure of PDB 5c91 Chain A

Receptor sequence
>5c91A (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
SRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADF
LKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTL
QINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKP
ITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNG
GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIF
DENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSE
KRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPEKLPRAHTCF
NRLDLPPYESFEELWDKLQMAIENT
3D structure
PDB5c91 A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism.
ChainA
Resolution2.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R549 E580 E591 D653 H865 C867
Catalytic site (residue number reindexed from 1) R31 E62 E73 D135 H347 C349
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4YU A Y605 L607 C627 N628 Y87 L89 C109 N110 PDBbind-CN: -logKd/Ki=3.61,Ki=245.8uM
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity

View graph for
Molecular Function
External links
PDB RCSB:5c91, PDBe:5c91, PDBj:5c91
PDBsum5c91
PubMed26371805
UniProtP46934|NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4 (Gene Name=NEDD4)

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