Structure of PDB 5c7d Chain A

Receptor sequence
>5c7dA (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
NFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKV
KCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSL
EECLVR
3D structure
PDB5c7d Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C300 C303 H320 C327 C52 C55 H72 C79
BS02 4YF A K297 G306 L307 T308 D309 W310 E314 Q319 W323 Y324 K49 G58 L59 T60 D61 W62 E66 Q71 W75 Y76 MOAD: ic50=7.7uM
PDBbind-CN: -logKd/Ki=5.11,IC50=7.7uM
External links
PDB RCSB:5c7d, PDBe:5c7d, PDBj:5c7d
PDBsum5c7d
PubMed26218264
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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