Structure of PDB 5c7a Chain A

Receptor sequence
>5c7aA (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
NFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKV
KCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSL
EECLVR
3D structure
PDB5c7a Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C300 C303 H320 C327 C52 C55 H72 C79
BS02 4YE A G306 T308 D309 W310 E314 Q319 W323 Y324 G58 T60 D61 W62 E66 Q71 W75 Y76 PDBbind-CN: -logKd/Ki=3.31,IC50=495uM
External links
PDB RCSB:5c7a, PDBe:5c7a, PDBj:5c7a
PDBsum5c7a
PubMed26218264
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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