Structure of PDB 5c37 Chain A

Receptor sequence
>5c37A (length=632) Species: 9606 (Homo sapiens) [Search protein sequence]
EQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKAQIPRD
PSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSP
ALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTA
TDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAAL
GDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSGQGILSQDAW
ESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVES
LKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNL
SSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDSKTGC
PAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRR
WRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLE
NQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQ
SNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVS
GTLPQRMASCLEVLDLFLNQPHMVLSSFVLAE
3D structure
PDB5c37 Design and Synthesis of a Series of Bioavailable Fatty Acid Synthase (FASN) KR Domain Inhibitors for Cancer Therapy
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
1.3.1.39: enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific).
2.3.1.38: [acyl-carrier-protein] S-acetyltransferase.
2.3.1.39: [acyl-carrier-protein] S-malonyltransferase.
2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I.
2.3.1.85: fatty-acid synthase system.
3.1.2.14: oleoyl-[acyl-carrier-protein] hydrolase.
4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase.
Interaction with ligand
External links
PDB RCSB:5c37, PDBe:5c37, PDBj:5c37
PDBsum5c37
PubMed29779975
UniProtP49327|FAS_HUMAN Fatty acid synthase (Gene Name=FASN)

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