Structure of PDB 5bxo Chain A

Receptor sequence
>5bxoA (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
SGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY
NRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN
VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD
TDIQDLLRGD
3D structure
PDB5bxo Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.
ChainA
Resolution1.334 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R525 S527 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 K602 R39 S41 F46 G49 Y50 L74 N79 Y83 H85 D103 W105 F107 E112 K116
External links
PDB RCSB:5bxo, PDBe:5bxo, PDBj:5bxo
PDBsum5bxo
PubMed28084734
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

[Back to BioLiP]