Structure of PDB 5bwl Chain A

Receptor sequence
>5bwlA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDL
ATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRV
VVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALS
GKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEV
DRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRF
RFHFQGPCGTTLPEALA
3D structure
PDB5bwl Crystal Structure of SIRT5 in Complex with a Coumarin-Labelled Succinyl Peptide
ChainA
Resolution1.548 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V67 P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) V32 P33 T34 F35 R36 N106 D108 H123
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y102 R105 I142 V221 W222 G224 E225 L227 L232 Y255 M259 Y67 R70 I107 V186 W187 G189 E190 L192 L197 Y220 M224
BS02 ZN A C166 C169 C207 C212 C131 C134 C172 C177
BS03 MCM A R71 F223 Y255 R36 F188 Y220
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

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Molecular Function
External links
PDB RCSB:5bwl, PDBe:5bwl, PDBj:5bwl
PDBsum5bwl
PubMed
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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