Structure of PDB 5bvw Chain A

Receptor sequence
>5bvwA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
DFPRSRLRFKEKLGEGQFGEVHLCEVDSHPLLVAVKILRPDATKNARNDF
LKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE
DKPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA
DFGLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL
MLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRC
WSRESEQRPPFSQLHRFLAEDALN
3D structure
PDB5bvw Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.
ChainA
Resolution1.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D766 R770 N771 D784 A793
Catalytic site (residue number reindexed from 1) D133 R137 N138 D151 A156
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 A A653 K655 M676 T701 Y703 M704 E705 G707 L773 F785 A34 K36 M57 T82 Y84 M85 E86 G88 L140 F152 PDBbind-CN: -logKd/Ki=8.82,IC50=0.0015uM
BindingDB: Kd=0.69nM,IC50=4.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5bvw, PDBe:5bvw, PDBj:5bvw
PDBsum5bvw
PubMed26191369
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

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