Structure of PDB 5btd Chain A

Receptor sequence
>5btdA (length=487) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
IEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGF
RPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQG
NFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPT
VLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEE
TLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSR
GRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRI
VIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRY
YVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETV
DIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIAD
LEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAI
3D structure
PDB5btd Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
ChainA
Resolution2.497 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R39 V51 H52 H85 H87 R98 I181 R25 V37 H38 H71 H73 R84 I167
BS02 dna A Y28 R128 Y129 I181 G184 Y14 R114 Y115 I167 G170
BS03 dna A R39 H52 H85 H87 S95 I181 R25 H38 H71 H73 S81 I167
BS04 dna A Y28 R128 Y129 I181 A182 G184 M185 R248 Y14 R114 Y115 I167 A168 G170 M171 R234
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5btd, PDBe:5btd, PDBj:5btd
PDBsum5btd
PubMed26792525
UniProtP9WG47|GYRA_MYCTU DNA gyrase subunit A (Gene Name=gyrA)

[Back to BioLiP]