Structure of PDB 5bt4 Chain A

Receptor sequence
>5bt4A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5bt4 Crystal structure of BRD4 first bromodomain in complex with a 3,5-dimethylisoxazol ligand
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LO A W81 P82 L92 N140 I146 W40 P41 L51 N99 I105 BindingDB: Kd=8.5e+2nM,IC50=7121nM
External links
PDB RCSB:5bt4, PDBe:5bt4, PDBj:5bt4
PDBsum5bt4
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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