Structure of PDB 5bt3 Chain A

Receptor sequence
>5bt3A (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPM
DLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSE
VFEQEIDPVMQSLG
3D structure
PDB5bt3 Crystal structure of EP300 bromodomain in complex with a 3,5-dimethylisoxazol ligand
ChainA
Resolution1.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2LO A P1074 Q1077 V1079 L1084 R1137 V1138 Y1141 P27 Q30 V32 L37 R90 V91 Y94 BindingDB: Kd=31847134nM,IC50=230nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5bt3, PDBe:5bt3, PDBj:5bt3
PDBsum5bt3
PubMed
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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