Structure of PDB 5brt Chain A

Receptor sequence
>5brtA (length=554) Species: 1437882 (Pseudomonas nitroreducens HBP1) [Search protein sequence]
AETDVLIVGAGPAGAMSATLLASLGIRSLMINRWRSTSPGPRSHIINQRT
MEILRDIGLEESAKSLAVPKEYMGEHVYATSLAGEEFGRIPAWASHPQAH
AEHELASPSRYCDLPQLYFEPMVVSEAALRGADVRFLTEYLGHVEDQDGV
TARLLDHVSGAEYEVRAKYIIGADGAHSLVAQNAGLPFEGGSINIEFSAD
LSSLCEHKGDMYWMFGVAALRMIRPWNKWICVWGTKEEAKKIIHEIIGTD
EIPVEVGPISTWTINQQYAVRNTSGRVFCMGDAVHRHTPMGGLGLNTSVQ
DAYNLAWKLALVLKGTAAPTLLDSYDAERSPVAKQIVERAFKSLSTFPPV
FEALSLPPAPTESEMAEALVRLKDASEEGAKRRAALRKAMDATIIGLGGG
HGVELNQRYVSRAVFPDGTPDPGFVRDQEFFYQASTRPGAHLPHVWLTEN
QRRISTLDLCGKGRFTLLTGLSGAAWKHEAEQVSQSLGIELKVCVIGPGQ
EFVDTYGEYAKISEIGESGALLVRPDMFIAFRAKDASREGLEQLNVAVKS
ILGR
3D structure
PDB5brt A crystal structure of 2-hydroxybiphenyl 3-monooxygenase with bound substrate provides insights into the enzymatic mechanism.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H48 G237 I251 P320
Catalytic site (residue number reindexed from 1) H44 G216 I230 P289
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G13 G15 P16 A17 N36 R37 W38 R46 S47 Q120 E143 Y144 A177 D178 G179 W293 G312 D313 P320 G9 G11 P12 A13 N32 R33 W34 R42 S43 Q116 E139 Y140 A173 D174 G175 W262 G281 D282 P289
BS02 CH9 A H48 W97 M223 V253 P320 M321 H44 W93 M211 V232 P289 M290
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0071949 FAD binding

View graph for
Molecular Function
External links
PDB RCSB:5brt, PDBe:5brt, PDBj:5brt
PDBsum5brt
PubMed26275805
UniProtO06647

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