Structure of PDB 5brk Chain A

Receptor sequence
>5brkA (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
SKTFKPKKNIPEELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDF
FNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTPIKCSAPKYIDYL
MTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFD
SVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLG
3D structure
PDB5brk Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C79 C84 H161 H166 C65 C70 H143 H148
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030295 protein kinase activator activity
GO:0043539 protein serine/threonine kinase activator activity
GO:0046872 metal ion binding
Biological Process
GO:0035329 hippo signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5brk, PDBe:5brk, PDBj:5brk
PDBsum5brk
PubMed26108669
UniProtQ9H8S9|MOB1A_HUMAN MOB kinase activator 1A (Gene Name=MOB1A)

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