Structure of PDB 5bnw Chain A

Receptor sequence
>5bnwA (length=694) Species: 9606 (Homo sapiens) [Search protein sequence]
PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQ
QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ
INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL
QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAI
AERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHL
MQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGK
AADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALF
MDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDI
YDNRIVLNGIDLKAFLDSLPDVKIVKMKNMPVIPMNTIAEAVIEMINRGQ
IQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVY
CNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMG
LPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMV
TMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVR
GKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK
3D structure
PDB5bnw The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H496 H498 H499 N557 P559 T633 K634 H183 H185 H186 N244 P246 T320 K321
BS02 12V A H498 P559 T560 L653 P656 F694 K842 L866 V895 A896 K898 H901 H920 T921 T922 D925 H185 P246 T247 L340 P343 F381 K508 L532 V561 A562 K564 H567 H586 T587 T588 D591
External links
PDB RCSB:5bnw, PDBe:5bnw, PDBj:5bnw
PDBsum5bnw
PubMed26237509
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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