Structure of PDB 5b6d Chain A

Receptor sequence
>5b6dA (length=316) Species: 504097 (Streptomyces rimofaciens) [Search protein sequence]
TFGTFQDAYLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHIS
VPARRANVVFNFAEALWYLSGSDRLDFIQYYAPGIAAYSADGRTLRGTAY
GPRIFRHPAGGVNQWENVVKTLTDDPDSKRAVIQIFDPRELAVADNIDVA
CTLALQFLIRDGLLCGIGYMRANDAFRGAVSDVFSFTFLQEFTARYLGLG
IGTYHHVVGSVHIYDSDARWAERVLDAGFPAMPDGDNWPHVRRVLEWEER
LRTNAARLSADALDALDLPAYWKHVVALFEAHRQVRHEDTPDRALLAALP
EVYRQSLAVKWPGHFG
3D structure
PDB5b6d Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E68
Catalytic site (residue number reindexed from 1) E64
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P A R31 C155 R175 N177 D178 D186 H216 Y218 R27 C151 R171 N173 D174 D182 H212 Y214
BS02 C5P A K133 R134 K129 R130
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5b6d, PDBe:5b6d, PDBj:5b6d
PDBsum5b6d
PubMed28000775
UniProtB4Y380

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