Structure of PDB 5b5b Chain A

Receptor sequence
>5b5bA (length=249) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SPLKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLS
MLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRS
NQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNL
HEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPG
SHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
3D structure
PDB5b5b Helix12-Stabilization Antagonist of Vitamin D Receptor
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 D253 K260 P412 E416 I67 K71 D82 K89 P241 E245
BS02 AKX A Y143 L223 L226 V230 S233 R270 S271 S274 W282 C284 V296 A299 H393 Q396 Y30 L52 L55 V59 S62 R99 S100 S103 W111 C113 V125 A128 H222 Q225 MOAD: ic50=0.43nM
PDBbind-CN: -logKd/Ki=9.37,IC50=0.43nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5b5b, PDBe:5b5b, PDBj:5b5b
PDBsum5b5b
PubMed27294600
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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