Structure of PDB 5b4w Chain A

Receptor sequence
>5b4wA (length=434) Species: 9606 (Homo sapiens) [Search protein sequence]
TAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLD
SRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLG
QLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSI
PPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFL
FLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAV
ATSREVAHGEVLFAAFSSAGASALCAFPLDEVDRLANRTRDACYTREGRA
EDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPI
LEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSI
QQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVAS
3D structure
PDB5b4w Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F294 P325 T395 P396 I397 E399 D414 G415 H416 T417 L433 G434 S437 F263 P278 T348 P349 I350 E352 D367 G368 H369 T370 L386 G387 S390
BS02 peptide A S241 R245 G270 R272 T351 E352 P391 S210 R214 G239 R241 T304 E305 P344
Gene Ontology
Molecular Function
GO:0017154 semaphorin receptor activity
Biological Process
GO:0071526 semaphorin-plexin signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5b4w, PDBe:5b4w, PDBj:5b4w
PDBsum5b4w
PubMed27984026
UniProtO43157|PLXB1_HUMAN Plexin-B1 (Gene Name=PLXNB1)

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